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KMID : 0380620090410040446
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Korean Journal of Food Science and Technology
2009 Volume.41 No. 4 p.446 ~ p.451
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Anti-Obesitic Effects of Cathepsin S Inhibitory FractionDerived from Paecilomyces tenuipes in Mice Fed a High-Fat Diet
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Heo Gun
Myuong Kil-Sun
Lee Jung-Hee
Huh Chul-Sung
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Abstract
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In this study, cathepsin S (CTSS) inhibitory fraction was isolated from Paecilomyces tenuipes and anti-obesiticeffects of the fraction were evaluated in mice, fed a high-fat diet. Hot water extract of P. tenuipes (DHW) was dividedinto 2 fractions, water eluate fraction (DHP1) and methanol eluate fraction (DHP2) using Diaion HP-20. IC50 values forDHW, DHP1 and DHP2 against CTSS were 108.7, 890.3 and 2.3μg/mL, respectively. To evaluate anti-obesitic effects ofthe fractions, each fraction was administrated orally to C57BL/6 mice for 4 weeks with a high-fat diet. DHP2 had thehighest inhibitory effect on CTSS activity, causing serious reduction in weight gain, a reduction in the amount of adiposetissue and in serum lipids levels. These results suggest that the inhibition of CTSS by compounds derived from P. tenuipesmay be effective in preventing and in ameliorating obesity.
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KEYWORD
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Peacilomyces tenuipes, obesity, cathepsin S
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